Mechanism of Release of Ferritin Iron In Vivo by Xanthine Oxidase1

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Hepatic Xanthine Oxidase and Ferritin Iron in the Developing Rat.

By A. MAzUR AND A. CARLETON T HE RESULTS of studies in our laboratory’ lend support to the hypothesis that the release of iron from ferritin stores in the liver is mediated by the enzyme xanthine oxidase acting as a dehydrogenase. In this reaction the reduced enzyme, formed as a result of oxidation of xanthine or hypoxanthine to uric acid, is reoxidized by some of the ferric iron of ferritin wh...

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Hepatic Xanthine Oxidase and Ferritin Iron in the Developing Rat

By A. MAzUR AND A. CARLETON T HE RESULTS of studies in our laboratory’ lend support to the hypothesis that the release of iron from ferritin stores in the liver is mediated by the enzyme xanthine oxidase acting as a dehydrogenase. In this reaction the reduced enzyme, formed as a result of oxidation of xanthine or hypoxanthine to uric acid, is reoxidized by some of the ferric iron of ferritin wh...

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Hepatic Xanthine Oxidase and Ferritin Iron in the Developing Rat

By A. MAzUR AND A. CARLETON T HE RESULTS of studies in our laboratory’ lend support to the hypothesis that the release of iron from ferritin stores in the liver is mediated by the enzyme xanthine oxidase acting as a dehydrogenase. In this reaction the reduced enzyme, formed as a result of oxidation of xanthine or hypoxanthine to uric acid, is reoxidized by some of the ferric iron of ferritin wh...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1958

ISSN: 0021-9738

DOI: 10.1172/jci103774